ABSTRACT
Coronavirus disease-2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may have a direct effect on several endocrine glands, including the thyroid. 1 SARS-CoV-2 enters cells using the angiotensin-converting enzyme-2 (ACE-2) receptor, expressed by the thyroid. 2 Prior literature reported low levels of triiodothyronine (TT3) and thyroid stimulating hormone (TSH) in adult patients with COVID-19. 3 However, levels of TSH in children during the pandemic are unknown. Wang et al., evaluated thyroid function in 96 hospitalized adults with COVID-19 3;levels of TSH were significantly lower than those of healthy controls. 3 Levels of TSH increased gradually within 2 months after hospitalization. 3 Similarly, Chen et al. reported TSH levels lower than the normal range in 28 of 50 (56%) adult patients with COVID-19. 5 It is unknown what caused the observed pattern and/or how significant it was. TSH levels may also differ according to ethnicity and race;discrepancies may exist between Asian, White, Black, and Hispanics. [...]this finding may only reflect one specific community representation, and may not apply to non-White children.